This presentation provides an in-depth explanation of post-traumatic stress disorder (PTSD) and other psychological disorders, including generalized anxiety disorder (GAD), and major depressive disorder (MDD). We cover the criteria required for determining each diagnosis along with claims handling nuances for consideration of presumption, relatedness, extent of injury, and return to work. The information provides understanding for when questions arise in claims adjusting, such as: the presence, role, and impact of psychological factors in all types of claims, including the reaction to and recovery from workers’ compensation injuries. We look at four occupational psychological injury scenarios and discuss which type of disorder is present based on criteria for each disorder learned. We also discuss the presumption of on-the-job and in-the-line-of-duty relatedness and extent of injury for these scenarios.